Articles in this issue

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  The biggest challenges in cell and gene therapy

  Monday, February 03, 2025
  To benchmark the sector’s progress in the inaugural issue of Cell & Gene Therapy Review, we asked thought leaders a single question: What is the biggest challenge facing the CGT sector in 2025? read more
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  Charting a path with biomarker discovery tools

  Tuesday, February 11, 2025
  Biomarkers have become indispensable in the creation and optimization of cutting-edge treatments. read more
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  Within reach: Bringing cell and gene therapies to under-resourced regions

  Tuesday, February 18, 2025
  As multiple stakeholders come at the problem from different angles, sustainable global access pathways are beginning to align. From process efficiencies aimed at reining in costs to innovative manufacturing and go-to-market models, cell and gene therapies are charting a course towards future ... read more
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  Written in the CARs

  Tuesday, February 25, 2025
  To quote Astronomers Without Borders, “Boundaries vanish when we look skyward.” In a perfect world, this same philosophy would guide global access to cell and gene therapies. read more
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  A standardized approach to CGT quality management

  Wednesday, March 05, 2025
  This article describes the thought processes involved in defining control strategies across important areas including aseptic control, material control, process control, quality control and chain of custody control. We offer examples of how each of these elements should be developed and documented ... read more
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  Advancing AAV production

  Friday, March 28, 2025
  As the therapeutic potential of AAV gene therapy becomes increasingly evident, so does the demand for its widespread application; however, this surge in demand poses a formidable challenge in the need for increasingly scalable and efficient AAV production platforms. Leveraging recent advances in ... read more
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  Considerations for successful scale-up and viral vector purification

  Wednesday, March 19, 2025
  To scale up a process, there are several important considerations, starting with the selection of a target batch size. However, process scale-up can encounter challenges. Here, several key considerations will be discussed, and specific examples of potential challenges faced during the scale-up of ... read more
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  Orchestrating cell and gene therapies

  Tuesday, March 25, 2025
  An effective orchestration platform is now essential in optimizing processes, fostering collaboration, and ensuring the safe and effective administration of CGTs. These orchestration platforms are crucial tools for approved treatment center staff to navigate the complex processes involved in CGT ... read more
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  Is CGT ready for prime time?

  Tuesday, March 11, 2025
  While challenges with commercial rollouts have been attributed to clinical site readiness, reimbursement coverage and accessibility, CGT drugs to date have predominantly targeted relatively small patient populations, effectively sidestepping a critical question: Are CGT manufacturing capabilities ... read more
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  A new era in cancer care

  Thursday, March 13, 2025
  Immunotherapy has transformed the field of oncology by harnessing the immune system’s innate ability to mount targeted attacks on cancer cells. Building on this foundation, cell and gene therapies take immunotherapy to the next level by reprogramming genetic blueprints and engineering immune cells ... read more